Mitochondrial Ca2+ remodeling is a prime factor in oncogenic behavior

Mitochondrial Ca2+ remodeling is a prime factor in oncogenic behavior

Blog Article

Cancer is sustained by defects in the mechanisms underlying cell proliferation, mitochondrial royal nomadic 5413 rug metabolism and cell death.Mitochondrial Ca2+ ions are central to all these processes, serving as signaling molecules with specific spatial localization, magnitude and temporal characteristics.Mutations in mtDNA, aberrant expression and/or regulation of Ca2+-handling/transport proteins, and abnormal Ca2+-dependent relationships among the cytosol, endoplasmic reticulum and mitochondria can cause the deregulation of mitochondrial Ca2+-dependent merrick backcountry wet cat food pathways that are related to these processes, thus determining oncogenic behavior.

In this review, we propose that mitochondrial Ca2+ remodeling plays a pivotal role in shaping the oncogenic signaling cascade, which is a required step for cancer formation and maintenance.We will describe recent studies that highlight the importance of mitochondria in inducing pivotal cancer hallmarks and discuss possible tools to manipulate mitochondrial Ca2+ to modulate cancer survival.